Phenotypes Associated with This Genotype

Genotype
MGI:5526092

• Allelic Composition: Itgb2^tm1.1Arte/Itgb2^tm1.1Arte
• Genetic Background: involves: C57BL/6NTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

enlarged spleen ( J:202261 )

increased neutrophil cell number ( J:202261 )

• circulating

increased dendritic cell number ( J:202261 )

• in the spleen

increased B cell number ( J:202261 )

• in the spleen

increased T cell number ( J:202261 )

• in the spleen

• however, regulatory T cell numbers are normal in the spleen

abnormal T cell physiology ( J:202261 )

• impaired adhesion under static conditions and reduced adhesion strength under shear stress

• impaired 2-dimensional migration of effector T cells

• impaired homing of CD4 T cells to lymph nodes

• however, IL2 production in response to anti-CD3 antibodies is normal

decreased T cell proliferation ( J:202261 )

• in response to anti-CD3 antibodies

lymph node hypoplasia ( J:202261 )

hematopoietic system

enlarged spleen ( J:202261 )

increased neutrophil cell number ( J:202261 )

• circulating

increased dendritic cell number ( J:202261 )

• in the spleen

increased B cell number ( J:202261 )

• in the spleen

increased T cell number ( J:202261 )

• in the spleen

• however, regulatory T cell numbers are normal in the spleen

abnormal T cell physiology ( J:202261 )

• impaired adhesion under static conditions and reduced adhesion strength under shear stress

• impaired 2-dimensional migration of effector T cells

• impaired homing of CD4 T cells to lymph nodes

• however, IL2 production in response to anti-CD3 antibodies is normal

decreased T cell proliferation ( J:202261 )

• in response to anti-CD3 antibodies

growth/size/body

enlarged spleen ( J:202261 )

cellular

decreased T cell proliferation ( J:202261 )

• in response to anti-CD3 antibodies