Phenotypes Associated with This Genotype

Genotype
MGI:5526062

• Allelic Composition: Cd22^tm3Lnit/Cd22^tm3Lnit
• Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:198790 )

N • early B cell development in bone marrow is normal

abnormal immune system morphology ( J:198790 )

decreased B cell number ( J:198790 )

• reduced B cell numbers in the blood

decreased transitional stage B cell number ( J:198790 )

• reduced transitional T1 and T2 B cells in the spleen

absent mature B cells ( J:198790 )

• lack of mature recirculating B cells in bone marrow

decreased marginal zone B cell number ( J:198790 )

• reduced in number

abnormal immune system physiology ( J:198790 )

abnormal B cell physiology ( J:198790 )

• increased B cell turnover

increased B cell apoptosis ( J:198790 )

increased IgG1 level ( J:198790 )

• increased IgG1 in response to thymus dependent antigens

autoimmune response ( J:198790 )

• increased Calcium ion response to anti-IgM

• at low doses response is greater the in Cd22^tm3Lnit

cellular

increased B cell apoptosis ( J:198790 )

decreased cell migration ( J:198790 )

• migration of B cells to bone marrow is reduced

hematopoietic system

decreased B cell number ( J:198790 )

• reduced B cell numbers in the blood

decreased transitional stage B cell number ( J:198790 )

• reduced transitional T1 and T2 B cells in the spleen

absent mature B cells ( J:198790 )

• lack of mature recirculating B cells in bone marrow

decreased marginal zone B cell number ( J:198790 )

• reduced in number

abnormal B cell physiology ( J:198790 )

• increased B cell turnover

increased B cell apoptosis ( J:198790 )

increased IgG1 level ( J:198790 )

• increased IgG1 in response to thymus dependent antigens