Cd22^tm3Lnit
Targeted Allele Detail

Summary

• Symbol: Cd22^tm3Lnit
• Name: CD22 antigen; targeted mutation 3, Lars Nitschke
• MGI ID: MGI:5526058
• Synonyms: Cd22^Y2,5,6F
• Gene: Cd22 Location: Chr7:30564829-30579767 bp, - strand Genetic Position: Chr7, 19.26 cM
• Alliance: Cd22^tm3Lnit page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:198790
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted
• Mutation: Nucleotide substitutions
• Mutation details: Point mutations were inserted in exons 14 and 16 at codons 783, 843, anf 863 which changed the encoded amino acids from tyrosine to phenylalanine. (J:198790)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cd22 Mutation: 63 strains or lines available

References

• Original: J:198790 Muller J, et al., CD22 ligand-binding and signaling domains reciprocally regulate B-cell Ca2+ signaling. Proc Natl Acad Sci U S A. 2013 Jul 23;110(30):12402-7
• All: 2 reference(s)