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Phenotypes Associated with This Genotype
Genotype
MGI:5524280
Allelic
Composition		 \Gt(ROSA)26Sortm1(TMPRSS2/ERG)Key/\Gt(ROSA)26Sortm1(TMPRSS2/ERG)Key
\Ptentm2.1Ppp/\Ptentm2.1Ppp
\Tg(Pbsn-cre)4Prb/0
Genetic
Background		 involves: 129S1/Sv * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(TMPRSS2/ERG)Key mutation (2 available); any Gt(ROSA)26Sor mutation (1097 available)
Ptentm2.1Ppp mutation (0 available); any Pten mutation (87 available)
Tg(Pbsn-cre)4Prb mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:200002 )
• shortened survival compared with Ptentm2.1Ppp/Ptentm2.1Ppp Tg(Pbsn-cre)4Prb mice

reproductive system
enlarged prostate gland ( J:200002 )
• enlarged and hardened by 6 months
increased prostate gland adenocarcinoma incidence ( J:200002 )
• invasive with small irregular glandular structures composed of malignant cells with large, pleiomorphic nuclei and pale cytoplasm by 8 weeks
increased prostate intraepithelial neoplasia incidence ( J:200002 )
• with a proliferative index only slightly higher than in Ptentm2.1Ppp/Ptentm2.1Ppp Tg(Pbsn-cre)4Prb mice
abnormal prostate gland physiology ( J:200002 )
• proliferative index only slightly higher than in Ptentm2.1Ppp/Ptentm2.1Ppp Tg(Pbsn-cre)4Prb mice

neoplasm
increased prostate gland adenocarcinoma incidence ( J:200002 )
• invasive with small irregular glandular structures composed of malignant cells with large, pleiomorphic nuclei and pale cytoplasm by 8 weeks
increased prostate intraepithelial neoplasia incidence ( J:200002 )
• with a proliferative index only slightly higher than in Ptentm2.1Ppp/Ptentm2.1Ppp Tg(Pbsn-cre)4Prb mice

renal/urinary system

growth/size/body
distended abdomen ( J:200002 )
• increased abdominal girth

endocrine/exocrine glands
enlarged prostate gland ( J:200002 )
• enlarged and hardened by 6 months
increased prostate gland adenocarcinoma incidence ( J:200002 )
• invasive with small irregular glandular structures composed of malignant cells with large, pleiomorphic nuclei and pale cytoplasm by 8 weeks
increased prostate intraepithelial neoplasia incidence ( J:200002 )
• with a proliferative index only slightly higher than in Ptentm2.1Ppp/Ptentm2.1Ppp Tg(Pbsn-cre)4Prb mice
abnormal prostate gland physiology ( J:200002 )
• proliferative index only slightly higher than in Ptentm2.1Ppp/Ptentm2.1Ppp Tg(Pbsn-cre)4Prb mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory