Phenotypes Associated with This Genotype

Genotype
MGI:5524268

• Allelic Composition: C1galt1^tm1.1Staka/C1galt1^tm1.2Staka; Tg(Mx1-cre)1Cgn/0
• Genetic Background: involves: C57BL/6 * C57BL/6J * CBA * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

hematopoietic system phenotype ( J:202276 )

N • pIpC-treated mice exhibit normal numbers of megakaryocytes in the bone marrow

abnormal megakaryocyte differentiation ( J:202276 )

• pIpC-treated mice exhibit abnormal morphology of terminally differentiated megakaryocytes

abnormal platelet morphology ( J:202276 )

• giant platelets with increased number of microtubule coils in pIpC-treated mice

thrombocytopenia ( J:202276 )

• severe in pIpC-treated mice whether or not mice are splenectomized

giant platelets ( J:202276 )

• in pIpC-treated mice

homeostasis/metabolism

increased bleeding time ( J:202276 )

• in pIpC-treated mice whether or not mice are splenectomized

cellular

abnormal megakaryocyte differentiation ( J:202276 )

• pIpC-treated mice exhibit abnormal morphology of terminally differentiated megakaryocytes