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Phenotypes Associated with This Genotype
Genotype
MGI:5524256
Allelic
Composition		 Nrg1tm4Cbm/Nrg1tm4.1Cbm
H2az2Tg(Wnt1-cre)11Rth/H2az2+
Genetic
Background		 involves: 129P2/OlaHsd * BALB/cJ * C57BL/6J * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2az2Tg(Wnt1-cre)11Rth mutation (2 available); any H2az2 mutation (25 available)
Nrg1tm4.1Cbm mutation (0 available); any Nrg1 mutation (56 available)
Nrg1tm4Cbm mutation (0 available); any Nrg1 mutation (56 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:199150 )
N
• mice exhibit normal myelination
abnormal muscle spindle morphology ( J:199150 )
• small diameter and few intrafusal fibers

behavior/neurological
impaired coordination ( J:199150 )
• on an inverted grid, mice loss their grip 5 times faster than control mice
abnormal gait ( J:199150 )
• impaired left/right coordination with frequent hopping

muscle
abnormal muscle spindle morphology ( J:199150 )
• small diameter and few intrafusal fibers

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/06/2026
MGI 6.24 		The Jackson Laboratory