Phenotypes Associated with This Genotype

Genotype
MGI:5524227

• Allelic Composition: Fbxw7^tm2Iaai/Fbxw7⁺; Tg(Mx1-cre)1Cgn/0
• Genetic Background: involves: C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

neoplasm ( J:200006 )

N • pIpC-treated mice do not develop leukemia

decreased tumor latency ( J:200006 )

• pIpC-treated mice infected with a retrovirus expression a truncated form of Notch1 that is constitutively cleaved in a ligand-independent manner or a Notch1 lacking the PEST domain exhibit shorted latency to development of leukemia

hematopoietic system

hematopoietic system phenotype ( J:200006 )

N • pIpC-treated mice exhibit normal numbers of hematopoietic stem cells and are more functionally competent than in cells from Fbxw7^tm1Iaai/Fbxw7⁺ Tg(Mx1-cre)1Cgn mice

immune system

immune system phenotype ( J:200006 )

N • pIpC-treated mice exhibit normal numbers of early T cell progenitors in the thymus