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Phenotypes Associated with This Genotype
Genotype
MGI:5524047
Allelic
Composition		 Gt(ROSA)26Sortm1(DTA)Riet/Gt(ROSA)26Sor+
Tg(Pomc-EGFP)1Low/0
Tg(Gnrh1-cre)1Dlc/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(DTA)Riet mutation (0 available); any Gt(ROSA)26Sor mutation (1062 available)
Tg(Gnrh1-cre)1Dlc mutation (1 available)
Tg(Pomc-EGFP)1Low mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
small ovary ( J:199640 )
• less pronounced than in Nhlh2tm2Thbr/Nhlh2tm2Thbr Tg(CMV-cre)1Cgn mice
decreased uterus weight ( J:199640 )
• less pronounced than in Nhlh2tm2Thbr/Nhlh2tm2Thbr Tg(CMV-cre)1Cgn mice

nervous system
decreased neuron number ( J:199640 )
• severe reduction in Pomc+ neurons

adipose tissue
increased abdominal adipose tissue amount ( J:199640 )
• increased visceral fat mass
• however, subcutaneous adipose weight is normal

endocrine/exocrine glands
small ovary ( J:199640 )
• less pronounced than in Nhlh2tm2Thbr/Nhlh2tm2Thbr Tg(CMV-cre)1Cgn mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/06/2026
MGI 6.24 		The Jackson Laboratory