Phenotypes Associated with This Genotype

Genotype
MGI:5524046

• Allelic Composition: Nhlh2^tm2Thbr/Nhlh2^tm2Thbr; Tg(Gnrh1-cre)1Dlc/0; Tg(Pomc-EGFP)1Low/0
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * C57BL/6J * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

reproductive system phenotype ( J:199640 )

N • mice exhibit normal uteri and testis weights

nervous system

decreased neuron number ( J:199640 )

• severe reduction in Pomc+ neurons in the medial preoptic area and posterior hypothalamus in male and female mice

• reduced Gnhr+ neurons in male and female mice

adipose tissue

increased white adipose tissue amount ( J:199640 )

• increased visceral fat mass weight in male and female mice but not as much as in Nhlh2^tm2Thbr/Nhlh2^tm2Thbr Tg(CMV-cre)1Cgn mice

• however, subcutaneous adipose weight is normal

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:199640 )

♀N • mice exhibit normal estradiol levels