About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:5523966
Allelic
Composition
Tg(Guca1a*L151F/EGFP)#Wbae/0
Genetic
Background
involves: C57BL/6J * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype

Slowly progressive photoreceptor degeneration in Tg(Guca1a*L151F/EGFP)#Wbae/0 and Tg(Guca1a*L151F)#Wbae/0 mice

nervous system
• mutants exhibit slowly progressing photoreceptor degeneration (cone-rod dystrophy) that begins to be seen at around 9 months

vision/eye
• mutants exhibit slowly progressing photoreceptor degeneration (cone-rod dystrophy) that begins to be seen at around 9 months
• thinning of the outer nuclear layer starts to be seen by 9 months of age and progresses to a 20% reduction by 1 year of age
• reduction in scotopic (a-wave) ERG amplitude starts to be seen by 9 months of age and is significantly attenuated by 12 months of age
• reduction in photopic (b-wave) ERG amplitude starts to be seen by 9 months of age and is significantly attenuated (40% reduction) by 12 months of age
• optomotry indicates a 15% reduction in visual acuity by 1 year of age

Mouse Models of Human Disease
OMIM ID Ref(s)
Cone Dystrophy 3; COD3 602093 J:199392


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
06/22/2016
MGI 6.04
The Jackson Laboratory