Phenotypes Associated with This Genotype

Genotype
MGI:5523965

• Allelic Composition: Tg(Guca1a*L151F)#Wbae/0
• Genetic Background: involves: C57BL/6J * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Slowly progressive photoreceptor degeneration in Tg(Guca1a*L151F/EGFP)#Wbae/0 and Tg(Guca1a*L151F)#Wbae/0 mice

nervous system

retina photoreceptor degeneration ( J:199392 )

• mutants exhibit slowly progressing photoreceptor degeneration (cone-rod dystrophy) that begins to be seen at around 9 months

vision/eye

retina photoreceptor degeneration ( J:199392 )

• mutants exhibit slowly progressing photoreceptor degeneration (cone-rod dystrophy) that begins to be seen at around 9 months

thin retina outer nuclear layer ( J:199392 )

• thinning of the outer nuclear layer starts to be seen by 9 months of age and progresses to a 20% reduction by 1 year of age

decreased a-wave amplitude ( J:199392 )

• reduction in scotopic (a-wave) ERG amplitude starts to be seen by 9 months of age and is significantly attenuated by 12 months of age

decreased b-wave amplitude ( J:199392 )

• reduction in photopic (b-wave) ERG amplitude starts to be seen by 9 months of age and is significantly attenuated (40% reduction) by 12 months of age

decreased visual acuity ( J:199392 )

• optomotry indicates a 15% reduction in visual acuity by 1 year of age