Phenotypes for Notch1 Notch2 MGI:5523684 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Notch1^tm1Con/Notch1⁺ Notch2^tm3.1Rko/Notch2^tm3.1Grid
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Notch1^tm1Con mutation (3 available); any Notch1 mutation (115 available)
Notch2^tm3.1Grid mutation (0 available); any Notch2 mutation (97 available)
Notch2^tm3.1Rko mutation (0 available); any Notch2 mutation (97 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

renal/urinary system

renal/urinary system phenotype ( J:198632 )

N	• kidneys have functional nephrons in normal numbers; one copy of the Notch1 intracellular domain (N1ICD) expressed from the Notch2 locus is sufficient for nephron formation

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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