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Phenotypes Associated with This Genotype
Genotype
MGI:5523486
Allelic
Composition
Exo1tm3.1Wed/Exo1tm3.1Wed
Genetic
Background
involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Exo1tm3.1Wed mutation (0 available); any Exo1 mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

reproductive system
N
• mice exhibit normal reproduction and meiosis

neoplasm
• without an increase in microsatellite instability
• more so than in Exo1tm2Wed homozygotes
• more so than in Exo1tm2Wed homozygotes

homeostasis/metabolism
N
• mice exhibit normal mutation frequency
• mouse embryonic fibroblasts exhibit impaired double strand break repair through DNA end resection compared with wild-type cells

immune system
N
• mice exhibit normal somatic hypermutation frequency and class switch recombination

cellular
• mouse embryonic fibroblasts exhibit impaired double strand break repair through DNA end resection compared with wild-type cells


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory