Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol: Exo1tm2Wed Name: exonuclease 1; targeted mutation 2, Winfried Edelmann MGI ID: MGI:5523452 Synonyms: Exo1null Gene: Exo1  Location: Chr1:175708334-175738962 bp, + strand  Genetic Position: Chr1, 81.9 cM Alliance: Exo1tm2Wed page

Decreased testis weight in Exo1tm2Wed/Exo1tm2Wed males Show the 3 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:198719
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A hygromycin resistance cassette was inserted between exon 4 and 5, replacing the intron. Western blot analysis confirmed the absence of protein expression in the testis. (J:198719)

Gene-targeting strategy for the Exo1tm2Wed allele

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Exo1 Mutation:	45 strains or lines available

Original:	J:198719 Schaetzlein S, et al., Mammalian Exo1 encodes both structural and catalytic functions that play distinct roles in essential biological processes. Proc Natl Acad Sci U S A. 2013 Jul 2;110(27):E2470-9
All:	2 reference(s)