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Phenotypes Associated with This Genotype
Genotype
MGI:5522686
Allelic
Composition
Robo2tm1Mrt/Robo2tm1Mrt
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Robo2tm1Mrt mutation (2 available); any Robo2 mutation (102 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• appears to be ventrally displaced and corticofugal axons abnormally defasciculate in some mice at E18.5
• at E18.5, a few corticofugal axons are ventrally displaced reaching the ventral midline at the level of the anterior commissure and occasional bundles of cortical fibers are found in the dorsal thalamus
• at E18.5, some thalamocortical fibers fail to reach the telencephalon and instead grow toward the ventral diencephalon and invade the hypothalamu


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
01/20/2026
MGI 6.24
The Jackson Laboratory