Phenotypes Associated with This Genotype

Genotype
MGI:5522567

• Allelic Composition: Atat1^{tm1(KOMP)Vlcg}/Atat1^{tm1(KOMP)Vlcg}
• Genetic Background: involves: C57BL/6 * C57BL/6NTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Dilated lateral ventricles and abnormal dentate gyrus morphology in Atat1^{tm1(KOMP)Vlcg}/Atat1^{tm1(KOMP)Vlcg} brains

nervous system

dilated lateral ventricle ( J:201922 )

abnormal dentate gyrus morphology ( J:201922 )

• slightly deformed with a prominent bulge in the lateral blade of the granular cell layer

cellular

abnormal cell physiology ( J:201922 )

• mice exhibit complete or dramatic loss of alpha tubulin acetylation in major tissues, including the testis, kidney, liver, lung and brain compared with wild-type mice