Mouse Genome Informatics
tg
    Tg(Thy1-Tcf4)1Mjro/0
involves: C57BL/6N * FVB/N
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
behavior/neurological
• the relative time spent in the center versus the periphery is slightly but significantly less then in controls during the dark phase under dim red light at Zeitgeber times 17-19, indicating altered level of anxiety that is not observed during the light phase at Zeitgeber times 4-6 (J:202664)
• mice, however, show similar activity, exploratory, motor and motivational behavior, and pain sensitivity as controls during light phase (Zeitgeber times 4-6) (J:202664)
• freezing performance in the novel context before conditioning and during the presentation of first auditory cue is normal, however mutants show more freezings during the presentation of tone 2 when compared with tone 1, indicating impaired trace fear conditioning (J:197081)
• in the remote trace memory test, during presentation of tone 1 and tone 2, mutants show less freezing and in the first interval of post-tone 1, mice also show less freezing than controls, indicating reduced remote trace fear memory formation (J:197081)
• in recent and remote trace memory tests, mutants show fewer freezings in a time window following auditory cue (post-tone), indicating a reduced ability to anticipate the aversive foot shock (J:197081)
• mice show fewer freezings than controls when trained in the trace paradigm (exposed on consecutive day to the same context as during conditioning), indicating impaired recent contextual fear memory (J:197081)
• prior to the cued trace memory test, mice show normal freezing behavior in a novel context, although mutants show a tendency toward lower freezing rate (J:197081)
• however, mutants show normal remote contextual memory and normal non-associate freezing and initial acquisition (J:197081)
• upon two foot-shocks, mice show reduced freezing in the contextual and cue memory tests, indicating impaired fear memory (J:202664)
• however, no significant differences are seen with five tone-food sock pairings (J:202664)
• contextual fear memory formation is slightly more altered during the dark phase at Zeitgeber times 17-19 compared with at Zeitgeber times 4-6 (J:202664)
• for the cued trace memory test in which mice were presented with 3 tones separated temporally by periods corresponding to trace intervals, mutants show less freezings during the presentation of tone 1, 2, and 3, indicating impaired trace fear memory (J:197081)
• upon two foot-shocks, mice show reduced freezing in the contextual and cue memory tests, indicating impaired fear memory (J:202664)
• cued fear memory formation is slightly more altered during the dark phase at Zeitgeber times 17-19 compared with at Zeitgeber times 4-6 (J:202664)
• on the first and second day of the reversal training on the water maze task, mice show greater escape latencies, indicating a slight impairment in cognitive flexibility (J:202664)
• however, mice exhibit proper visual perception and normal initial and reversal learning tasks (J:202664)

nervous system
• prepulse inhibition is impaired indicating impaired sensorimotor gating (J:202664)
• prepulse inhibition is impaired, most prominently at the 75 dB prepulse, indicating impaired sensorimotor gating (J:202664)
• however, startle response is normal (J:202664)

Mouse Models of Human Disease
OMIM IDRef(s)
Schizophrenia; SCZD 181500 J:197081