Phenotypes Associated with This Genotype

Genotype
MGI:5521180

• Allelic Composition: Gal3st1^tm1.1Hjg/Gal3st1^tm1.1Hjg; Ugcg^tm1Hjg/Ugcg^tm1Hjg; Pax8^{tm1.1(cre)Mbu}/Pax8⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

mortality/aging ( J:197393 )

N • normal life span

renal/urinary system

renal/urinary system phenotype ( J:197393 )

N • normal kidney morphology and creatinine clearance

abnormal urine homeostasis ( J:197393 )

decreased urine ammonia level ( J:197393 )

• decreased ammonium excretion

• reduced ability to increase urinary ammonia

increased urine potassium level ( J:197393 )

decreased urine pH ( J:197393 )

• higher excretion of titratable acid relative to controls

• less ability to recover from high acid in the diet

abnormal kidney papilla morphology ( J:197393 )

• ammonium content of the renal papilla is reduced 30% compared to controls

polyuria ( J:197393 )

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:197393 )

N • normal blood pH

N • normal blood bicarbonate levels

abnormal urine homeostasis ( J:197393 )

decreased urine ammonia level ( J:197393 )

• decreased ammonium excretion

• reduced ability to increase urinary ammonia

increased urine potassium level ( J:197393 )

decreased urine pH ( J:197393 )

• higher excretion of titratable acid relative to controls

• less ability to recover from high acid in the diet