Phenotypes Associated with This Genotype

Genotype
MGI:5520088

• Allelic Composition: Mmp14^tm1Stjw/Mmp14^tm1Stjw; Twist2^{tm1.1(cre)Dor}/Twist2⁺
• Genetic Background: involves: 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:198679 )

• 31 of 34 mice die by 120 to 150 days with no mice surviving beyond 10 months

skeleton

skeleton phenotype ( J:198679 )

N • mice exhibit normal osteoclast numbers

increased bone marrow adipose tissue amount ( J:198679 )

• increased bone marrow adiposity

domed cranium ( J:198679 )

decreased bone mineral density ( J:198679 )

abnormal cartilage morphology ( J:198679 )

• thickened articular cartilage

abnormal joint morphology ( J:198679 )

• thickened articular cartilage

abnormal bone ossification ( J:198679 )

delayed intramembranous bone ossification ( J:198679 )

delayed cranial suture closure ( J:198679 )

• failure of suture closure

growth/size/body

short snout ( J:198679 )

decreased body size ( J:198679 )

• by P4 to P5

decreased body weight ( J:198679 )

• by P4 to P5

postnatal growth retardation ( J:198679 )

• by P4 to P5

adipose tissue

increased bone marrow adipose tissue amount ( J:198679 )

• increased bone marrow adiposity

abnormal hypodermis fat layer morphology ( J:198679 )

• adipocytes that localized to dermal fat pads fail to generate subcutaneous fat

craniofacial

domed cranium ( J:198679 )

short snout ( J:198679 )

integument

abnormal hypodermis fat layer morphology ( J:198679 )

• adipocytes that localized to dermal fat pads fail to generate subcutaneous fat