Phenotypes Associated with This Genotype

Genotype
MGI:5520082

• Allelic Composition: Pcdh17^tm1.1Sia/Pcdh17^tm1.1Sia
• Genetic Background: involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

nervous system phenotype ( J:201552 )

N • mice exhibit normal corticobasal ganglia circuitry

N • mice exhibit normal average postsynaptic spine area, PSD length, synaptic cleft width and density of asymmetric synapses

N • mice exhibit normal basic properties of AMPA and NMDA receptors at corticostriatal synapses and synaptic transmission

abnormal synaptic vesicle number ( J:201552 )

• increased number of docked synaptic vesicles and total number of synaptic vesicles per presynaptic terminal in the inner, but not outer, lateral globus pallidus

decreased synaptic depression ( J:201552 )

• weaker depression of normalized excitatory postsynaptic current amplitude

• weaker synaptic depression following repetitive stimulation

abnormal paired-pulse inhibition ( J:201552 )

• increased paired-pulse ratio of inhibitory postsynaptic currents

behavior/neurological

behavior/neurological phenotype ( J:201552 )

N • mice exhibit normal spontaneous locomotor activity, anxiety-related behavior, fear learning, startle response and pain behavior

increased coping response ( J:201552 )

• mice spend less time immobile in a tail suspension test and forced swim test

cellular

abnormal synaptic vesicle number ( J:201552 )

• increased number of docked synaptic vesicles and total number of synaptic vesicles per presynaptic terminal in the inner, but not outer, lateral globus pallidus