Phenotypes Associated with This Genotype

Genotype
MGI:5519097

• Allelic Composition: Rb1^tm3Tyj/Rb1⁺; Trp53^tm1Brn/Trp53⁺; Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
• Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6J * CD-1 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:136693 )

• about 70% survival at 400 days of age, with some mice starting to die around 150 days of age

neoplasm

increased metastatic potential ( J:136693 )

• tumors show metastasis, most frequently to the lung and then the liver

increased osteosarcoma incidence ( J:136693 )

• develop osteosarcomas with a shortened latency (average of 198 days) and increased penetrance (30%) compared to single Trp53 heterozygotes

skeleton

increased osteosarcoma incidence ( J:136693 )

• develop osteosarcomas with a shortened latency (average of 198 days) and increased penetrance (30%) compared to single Trp53 heterozygotes