Phenotypes Associated with This Genotype

Genotype
MGI:5519096

• Allelic Composition: \Rb1^tm3Tyj/\Rb1^tm3Tyj; \Trp53^tm1Brn/\Trp53⁺; \Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
• Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6J * CD-1 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:136693 )

• mice start to die from around 125 days of age, although about 20% survive to 400 days of age

neoplasm

increased metastatic potential ( J:136693 )

• tumors show metastasis, most frequently to the lung and then the liver

increased osteosarcoma incidence ( J:136693 )

• 77.8% penetrance of osteosarcomas with an average latency of 177 days of age

skeleton

increased osteosarcoma incidence ( J:136693 )

• 77.8% penetrance of osteosarcomas with an average latency of 177 days of age