Phenotypes Associated with This Genotype

Genotype
MGI:5518648

• Allelic Composition: Sox11^tm1.1Gan/Sox11^tm1.1Gan; Sox4^tm1Vlf/Sox4^tm1Vlf; Tg(Six3-cre)69Frty/0
• Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Decrease in retinal ganglion cells in single Sox11^tm1.1Gan and Sox4^tm1Vlf homozygous conditional mutants and abolishment of retinal ganglion cells in Sox11^tm1.1Gan/Sox11^tm1.1Gan Sox4^tm1Vlf/Sox4^tm1Vlf Tg(Six3-cre)69Frty/0 retinas

mortality/aging

postnatal lethality, complete penetrance ( J:199663 )

• mice die before P14

vision/eye

increased retina apoptosis ( J:199663 )

• 6-fold increase starting at E14.5

• 10-fold increase starting at E16.5

decreased amacrine cell number ( J:199663 )

decreased retina ganglion cell number ( J:199663 )

• only a few cells present at E12.5

absent retina ganglion cell ( J:199663 )

abnormal retina bipolar cell morphology ( J:199663 )

• decreased number

absent optic nerve ( J:199663 )

abnormal eye development ( J:199663 )

• impaired retinal ganglion cell development

absent retina ganglion layer ( J:199663 )

• at E16.5

thin retina ganglion layer ( J:199663 )

• at E14.5

absent retina inner plexiform layer ( J:199663 )

abnormal retina outer plexiform layer morphology ( J:199663 )

• absent

growth/size/body

decreased birth body size ( J:199663 )

cellular

increased retina apoptosis ( J:199663 )

• 6-fold increase starting at E14.5

• 10-fold increase starting at E16.5

nervous system

decreased amacrine cell number ( J:199663 )

decreased retina ganglion cell number ( J:199663 )

• only a few cells present at E12.5

absent retina ganglion cell ( J:199663 )

abnormal retina bipolar cell morphology ( J:199663 )

• decreased number

absent optic nerve ( J:199663 )