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Phenotypes Associated with This Genotype
Genotype
MGI:5518623
Allelic
Composition
Tg(Pcp2-ATXN1*82Q)5Horr/Tg(Pcp2-ATXN1*82Q)5Horr
Genetic
Background
involves: FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological

nervous system
• Bergmann glial proliferation
• gliosis in the molecular layer
• occasionally Purkinje cells have large clear vacuoles within their cytoplasm
• significant loss of the Purkinje cell population
• the dendritic arrays are abnormal
• numerous ectopic Purkinje cells are present in the molecular layer and occasionally in the granular layer
• shrinkage and gliosis of the molecular layer

cellular
• Bergmann glial proliferation
• gliosis in the molecular layer


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/25/2025
MGI 6.24
The Jackson Laboratory