Mouse Genome Informatics
cn
    Ptentm1Hwu/Pten+
Tg(Nkx2-1-cre)2Sand/0

B6.Cg-Ptentm1Hwu Tg(Nkx2-1-cre)2Sand
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
endocrine/exocrine glands
• altered thyroid structure with normal areas that include colloid-filled follicles and normal areas with focal hyperplasia, polynuclear cells, small nonencapsulated areas of hypercellularity with solid and/or mircofollicular patterns and internal hemorrhage

homeostasis/metabolism
• P14 mutants show a mild decrease of T4 but normal TSH

tumorigenesis
• 100% of mutants develop differentiated follicular tumors of the thyroid after about 2 years of age

Mouse Models of Human Disease
OMIM IDRef(s)
Thyroid Carcinoma, Follicular; FTC 188470 J:197590