Phenotypes Associated with This Genotype

Genotype
MGI:5517675

• Allelic Composition: Pten^tm1Hwu/Pten⁺; Tg(Nkx2-1-cre)2Sand/0
• Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

abnormal thyroid follicle morphology ( J:197590 )

• enlarged follicles

enlarged thyroid gland ( J:197590 )

• mutants have an enlarged thyroid at 2 years of age and exhibit a goiter-like phenotype, but do not show development of tumors

thyroid gland hyperplasia ( J:197590 )

homeostasis/metabolism

increased thyroxine level ( J:197590 )

• P14 mutants show an increase in T4 levels