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Phenotypes Associated with This Genotype
Genotype
MGI:5517671
Allelic
Composition		 Asb2tm1.1Lutz/Asb2tm1.1Lutz
Tg(Mx1-cre)1Cgn/0
Genetic
Background		 involves: 129S2/SvPas * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Asb2tm1.1Lutz mutation (0 available); any Asb2 mutation (27 available)
Tg(Mx1-cre)1Cgn mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal dendritic cell physiology ( J:200966 )
• immature dendritic cells from pIpC-treated mice exhibit reduced spreading on a fibronectin coated surface, rosette podosome formation, ability to degrade the extracellular matrix and migrate through matrigel-coated filters compared with wild-type cells

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/06/2026
MGI 6.24 		The Jackson Laboratory