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Phenotypes Associated with This Genotype
Genotype
MGI:5517542
Allelic
Composition		 Ltb4r1tm1Tksh/Ltb4r1tm1Tksh
Genetic
Background		 C.Cg-Ltb4r1tm1Tksh
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ltb4r1tm1Tksh mutation (2 available); any Ltb4r1 mutation (20 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal mast cell physiology ( J:133998 )
• bone marrow-derived mast cells fail to migrate in response to LTB4 unlike wild-type cells
• however, bone marrow-derived mast cells exhibit normal migration in response to 12-12(S)-hydroxyheptadeca-5Z, 8E, 10E-trienoic acid (12-HHT) and stem cell factor (SCF)

hematopoietic system
abnormal mast cell physiology ( J:133998 )
• bone marrow-derived mast cells fail to migrate in response to LTB4 unlike wild-type cells
• however, bone marrow-derived mast cells exhibit normal migration in response to 12-12(S)-hydroxyheptadeca-5Z, 8E, 10E-trienoic acid (12-HHT) and stem cell factor (SCF)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory