Phenotypes Associated with This Genotype

Genotype
MGI:5516590

• Allelic Composition: Ark2c^Gt(P9-3F)Sor/Ark2c⁺; Smad9^tm1Rob/Smad9^tm1Rob; Tg(Hlxb9-GFP)1Tmj/0
• Genetic Background: involves: 129S/SvEv * C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:198828 )

• fewer than expected mice survive prior to weaning

prenatal lethality, incomplete penetrance ( J:198828 )

• fewer than expected mice are born

muscle

skeletal muscle atrophy ( J:198828 )

• unilateral penetrance in the muscles controlling the digits and wrist

behavior/neurological

decreased grip strength ( J:198828 )

• some mice exhibit reduced hang time from a cage lid compared with wild-type mice

nervous system

abnormal motor neuron innervation pattern ( J:198828 )

• reduction or loss of the most distal innervation in the forelimbs

skeleton

abnormal joint mobility ( J:198828 )

• as in Rnf165 homozygotes

limbs/digits/tail

abnormal forelimb morphology ( J:198828 )

• as in Rnf165 homozygotes