Phenotypes Associated with This Genotype

Genotype
MGI:5515807

• Allelic Composition: Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp; Tg(Tyr-NRAS*Q61K)1Bee/0
• Genetic Background: involves: 129/Sv * C57BL/6J * DBA/2 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

integument

skin lesions ( J:193443 )

• dermal lesions that resemble giant congenital naevi

increased cutaneous melanoma incidence ( J:193443 )

• 100% of mutants develop melanoma by 6 months of age

pigmentation

hyperpigmentation ( J:193443 )

• hyperpigmentation of the naevus nests close to the epidermis and naevus cells around and within hair follicles and other adnexal structures such as sebaceous glands

• skin hyperpigmentation is apparent at the first postnatal week and is restricted to the dermis

neoplasm

increased cutaneous melanoma incidence ( J:193443 )

• 100% of mutants develop melanoma by 6 months of age