Phenotypes Associated with This Genotype

Genotype
MGI:5514349

• Allelic Composition: Fasl^gld/Fasl^gld
• Genetic Background: B6.C3-Fasl^gld

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

impaired macrophage phagocytosis ( J:91058 )

• clearance of apoptotic material by macrophages is reduced

• mutants infused with lysophosphatidylcholine (LPC) show a greater accumulation of apoptotic debris in lymph nodes than similarly treated wild-type mice

enlarged spleen ( J:91058 )

increased spleen weight ( J:91058 )

abnormal lymph node morphology ( J:91058 )

• mutants exhibit an increase in apoptotic material in the lymph nodes

enlarged lymph nodes ( J:91058 )

• increase in lymph node size and weight

increased autoantibody level ( J:91058 )

• serum levels of anticardiolipin antibody are modestly elevated on a normal diet and are further elevated on a Western diet

increased anti-nuclear antigen antibody level ( J:91058 )

• high titers of anti-nuclear antigen antibodies (ANAs) on normal and Western diet

cellular

increased apoptosis ( J:91058 )

• mutants exhibit an increase in apoptotic material in the lymph nodes

impaired macrophage phagocytosis ( J:91058 )

• clearance of apoptotic material by macrophages is reduced

• mutants infused with lysophosphatidylcholine (LPC) show a greater accumulation of apoptotic debris in lymph nodes than similarly treated wild-type mice

hematopoietic system

impaired macrophage phagocytosis ( J:91058 )

• clearance of apoptotic material by macrophages is reduced

• mutants infused with lysophosphatidylcholine (LPC) show a greater accumulation of apoptotic debris in lymph nodes than similarly treated wild-type mice

enlarged spleen ( J:91058 )

increased spleen weight ( J:91058 )

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:91058 )

N • lipid levels are normal

cardiovascular system

cardiovascular system phenotype ( J:91058 )

N • mutants do not develop atherosclerotic lesions and do not show macrophage or T cell infiltration in the aorta

growth/size/body

enlarged spleen ( J:91058 )

increased spleen weight ( J:91058 )