Mouse Genome Informatics
cx
    Apoetm1Unc/Apoetm1Unc
Faslgld/Faslgld

B6.Cg-Faslgld Apoetm1Unc
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
cardiovascular system
• mutants on a Western diet for 12 weeks exhibit atherosclerotic lesions in the aorta (J:91058)
• aortae show higher levels of macrophage and T cell extravasation within lesions and higher levels of apoptotic cells within lesions than in single Apoe homozygotes (J:91058)
• treatment with mycophenolate mofetil decreases the severity of atherosclerosis seen in mice fed a Western diet (J:200141)
• lesion area of mutants fed a Western diet is greater than in single Apoe homozygotes, with a 3-fold increase in plaque area
• mutants on a normal diet exhibit larger atherosclerotic lesion area than single Apoe homozygotes
• aortae show macrophage and T cell extravasation within atherosclerotic lesions, showing a greater increase in macrophages and T cells than in single Apoe homozygotes

cellular
• mutants exhibit a 40% higher frequency of apoptotic material in the lymph nodes than single Fasl homozygotes
• higher levels of apoptotic cells are seen within atherosclerotic lesions than in single Apoe homozygotes

hematopoietic system
• total number of all T cell subsets is increased in the lymph nodes, however no differences in the percentages of CD4+, CD8+ or double negative T cells are seen
• on a Western and normal diet
• spleen weight is increased to almost double that seen in single Fasl homozygotes on a Western diet and 5-fold that seen in wild-type or single Apoe homozygotes (J:91058)
• treatment with mycophenolate mofetil, an immunosuppressive agent, reduces spleen weight (J:200141)
• IgG levels are elevated on both the normal and Western diet
• clearance of apoptotic material by macrophages is reduced even further compared to single Fasl homozygotes when fed a Western diet

homeostasis/metabolism
• decrease in high density lipoprotein levels compared to wild-type mice
• mutants become hypercholesterolemic on a Western diet but to a lesser extent than single Apoe homozygotes (J:91058)
• increase in low density lipoprotein (LDL) levels compared to wild-type mice
• increase in very low density lipoprotein (VLDL) levels compared to wild-type mice, however levels are lower than in single Apoe homozygotes
• mild increase in plasma triglyceride levels when fed a Western or normal diet

immune system
• aortae show macrophage and T cell extravasation within atherosclerotic lesions, showing a greater increase in macrophages and T cells than in single Apoe homozygotes
• total number of all T cell subsets is increased in the lymph nodes, however no differences in the percentages of CD4+, CD8+ or double negative T cells are seen
• on a Western and normal diet
• spleen weight is increased to almost double that seen in single Fasl homozygotes on a Western diet and 5-fold that seen in wild-type or single Apoe homozygotes (J:91058)
• treatment with mycophenolate mofetil, an immunosuppressive agent, reduces spleen weight (J:200141)
• IgG levels are elevated on both the normal and Western diet
• clearance of apoptotic material by macrophages is reduced even further compared to single Fasl homozygotes when fed a Western diet
• mutants exhibit a 40% higher frequency of apoptotic material in the lymph nodes than single Fasl homozygotes
• increase in lymph node size and weight both on the Western and normal diets; this increase is larger than in single Fasl homozygotes (J:91058)
• serum levels of anti-cardiolipin antibody are about 4-fold higher than in single Fasl homozygotes on both the normal and Western diets
• anti-nuclear antibody (ANA) titers are elevated compared to single Fasl homozygotes on a normal diet and further elevated by Western diet (J:91058)
• treatment with mycophenolate mofetil decreases the anti-nuclear antibody titer (J:200141)
• infiltration of inflammatory cells and modest crest formation

renal/urinary system
• infiltration of inflammatory cells and modest crest formation
• kidneys have larger, more cellular glomeruli (J:91058)
• treatment with mycophenolate mofetil decreases glomerular tuft size and cell count (J:200141)

Mouse Models of Human Disease
OMIM IDRef(s)
Apolipoprotein E; APOE 107741 J:91058
Systemic Lupus Erythematosus; SLE 152700 J:91058 , J:200141