Phenotypes Associated with This Genotype

Genotype
MGI:5514176

• Allelic Composition: Map3k7^tm1Mis/Map3k7^tm1Mis; H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺
• Genetic Background: involves: C57BL/6J * CBA/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Mandibular hypoplasia and cleft palate in Map3k7^tm1Mis/Map3k7^tm1MisH2az2^{Tg(Wnt1-cre)11Rth}/0 mice

mortality/aging

neonatal lethality, complete penetrance ( J:198588 )

craniofacial

abnormal craniofacial morphology ( J:198588 )

• generally stunted

decreased cranium height ( J:198588 )

short mandible ( J:198588 )

short maxilla ( J:198588 )

abnormal secondary palate development ( J:198588 )

• at E18, the secondary palate fails to form

• delayed rugal formation in vivo

palatal shelf hypoplasia ( J:198588 )

• at E13.5 without a defect in proliferation

cleft secondary palate ( J:198588 )

• in 13 of 16 mice

failure of palatal shelf elevation ( J:198588 )

• at E14.5, the tongue remains interposed between palatal shelves with failure of elevation

• however, palatal shelf elevation occurs in cultured mouse embryonic heads

skeleton

decreased cranium height ( J:198588 )

short mandible ( J:198588 )

short maxilla ( J:198588 )

digestive/alimentary system

abnormal secondary palate development ( J:198588 )

• at E18, the secondary palate fails to form

• delayed rugal formation in vivo

palatal shelf hypoplasia ( J:198588 )

• at E13.5 without a defect in proliferation

cleft secondary palate ( J:198588 )

• in 13 of 16 mice

failure of palatal shelf elevation ( J:198588 )

• at E14.5, the tongue remains interposed between palatal shelves with failure of elevation

• however, palatal shelf elevation occurs in cultured mouse embryonic heads

growth/size/body

abnormal secondary palate development ( J:198588 )

• at E18, the secondary palate fails to form

• delayed rugal formation in vivo

palatal shelf hypoplasia ( J:198588 )

• at E13.5 without a defect in proliferation

cleft secondary palate ( J:198588 )

• in 13 of 16 mice

failure of palatal shelf elevation ( J:198588 )

• at E14.5, the tongue remains interposed between palatal shelves with failure of elevation

• however, palatal shelf elevation occurs in cultured mouse embryonic heads