Phenotypes Associated with This Genotype

Genotype
MGI:5512977

• Allelic Composition: Pax6^{tm2(Pax6_i5a,Pax2)Xzh}/Pax6^{tm2(Pax6_i5a,Pax2)Xzh}
• Genetic Background: involves: 129S6/SvEvTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

No eye structure is seen in E15.5 homozygous Pax6^{tm2(Pax6_i5a,Pax2)Xzh} or Pax6^{tm2.1(Pax6_i5a,Pax2)Xzh} mutants

vision/eye

abnormal eye development ( J:198381 )

• no eye structure at E15.5

• failure of lends induction at E15.5

abnormal retina development ( J:198381 )

• disrupted retinal development with no patterning of optic vesicle into retinal pigmented epithelium, optic disc and neural retina

nervous system

abnormal neuronal precursor proliferation ( J:198381 )

• increased cell proliferation in the subventricular zone at E14.5 that is not as severe as in Pax6^Sey-Neu homozygotes

abnormal telencephalon development ( J:198381 )

• telecephalon patterning rescue is not as strong as in Pax6^{tm2.1(Pax6_i5a,Pax2)Xzh} homozygotes

thin cortical plate ( J:198381 )

• compared with wild-type mice

cellular

abnormal neuronal precursor proliferation ( J:198381 )

• increased cell proliferation in the subventricular zone at E14.5 that is not as severe as in Pax6^Sey-Neu homozygotes