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Phenotypes Associated with This Genotype
Genotype
MGI:5510724
Allelic
Composition
Hbbd3th/Hbb+
Tg(LCR-HBA1,LCR-HBB*)1Tow/0
Genetic
Background
involves: C57BL/6 * DBA/2J * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hbbd3th mutation (4 available); any Hbb mutation (46 available)
Tg(LCR-HBA1,LCR-HBB*)1Tow mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• spleen is 2-4 times larger than control

hematopoietic system
• spleen is 2-4 times larger than control
• mild anemia
• decreased red blood cell counts
• decreased hemoglobin concentration
• 90% of deoxygenated cells exhibit sickled shapes as compared to 1% of the transgene only mice
• sickled erythrocytes have projections or spicules similar to human sickled cells
• elevated reticulocyte counts

immune system
• spleen is 2-4 times larger than control

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
sickle cell anemia DOID:10923 OMIM:603903
J:127701


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/17/2022
MGI 6.19
The Jackson Laboratory