immune system
• B220+ B cells are almost undetectable
• spleens often with reduced B cell counts
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• both frequency and absolute numbers are increased
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• significant decrease in total cell numbers for CD4+ cells
• significant decrease in naive CD4+ T cell numbers
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• significant decrease in naive CD8+ T cell numbers
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• splemomegaly at a young age
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• unorganized or absent follicular structures in the spleen
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• T cell areas of the spleen are unorganized, particularly those affecting CD8+ cells
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• at a young age
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• severe immune dysregulation
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• increased activation of both CD4+ and CD8+ T cells
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hematopoietic system
• increased activation of both CD4+ and CD8+ T cells
|
• B220+ B cells are almost undetectable
• spleens often with reduced B cell counts
|
• both frequency and absolute numbers are increased
|
• significant decrease in total cell numbers for CD4+ cells
• significant decrease in naive CD4+ T cell numbers
|
• significant decrease in naive CD8+ T cell numbers
|
• splemomegaly at a young age
|
• unorganized or absent follicular structures in the spleen
|
• T cell areas of the spleen are unorganized, particularly those affecting CD8+ cells
|
growth/size/body
• splemomegaly at a young age
|
cellular
• increased activation of both CD4+ and CD8+ T cells
|