Phenotypes Associated with This Genotype

Genotype
MGI:5510144

• Allelic Composition: Kit^tm5.1Bsm/Kit⁺
• Genetic Background: involves: 129S1/Sv * C57BL/6J * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Cecal gastrointestinal stromal tumor and gastric/colonic interstatial cell of Cajal hyperplasia in Kit^tm5.1Bsm/Kit⁺ and Kit^tm4.1Bsm/Kit⁺ mice

mortality/aging

lethality, incomplete penetrance ( J:188434 )

premature death ( J:188434 )

neoplasm

increased gastrointestinal tumor incidence ( J:188434 )

• mice develop cecal tumors that are larger than in Kit^tm4.1Bsm heterozygotes

increased tumor growth/size ( J:188434 )

• compared to in Kit^tm4.1Bsm heterozygotes

digestive/alimentary system

interstitial cells of Cajal hyperplasia ( J:188434 )

• less pronounced in the stomach and colon than in Kit^tm4.1Bsm heterozygotes

increased gastrointestinal tumor incidence ( J:188434 )

• mice develop cecal tumors that are larger than in Kit^tm4.1Bsm heterozygotes

hematopoietic system

decreased mean corpuscular volume ( J:188434 )