About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:5509330
Allelic
Composition
Hbbd3th/Hbb+
Tg(LCR-HBA2,LCR-HBB*)1Cos/0
Genetic
Background
involves: C57BL/6J * CBA/J * DBA/2J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hbbd3th mutation (4 available); any Hbb mutation (46 available)
Tg(LCR-HBA2,LCR-HBB*)1Cos mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• large spleen in all adults

cellular
• frequency of mice at weaning is dependent on the genotype of the mother and is partly dependent on oxygen affinity of maternal erythrocytes; when hemizygous transgenic males are crossed with homozygous Hbbd3th females, frequency of progeny at weaning is only 9%, while for the reciprocal cross, it is 30% instead of the expected 50% for either cross

mortality/aging
• mutants are extremely sensitive to hypoxia, with 9 of 10 mice dying within 90 min of exposure to 8% oxygen
• progeny at weaning is less than expected; when hemizygous transgenic males are crossed with homozygous Hbbd3th females, frequency of progeny at weaning is only 9%, while for the reciprocal cross, it is 30% instead of the expected 50% for either cross

hematopoietic system
• large spleen in all adults
• neonates are slightly more anemic than single Tg(LCR-HBA2,LCR-HBB*)1Cos, showing a 37% reduction in hematocrit
• erythrocytes show abnormal size and shape, with 5-15% of erythrocytes being small and elongated, resembling irreversible sickle cells
• erythrocyte show heterogenous cell density, with a fraction of cells displaying high density
• most erythrocytes become sickled upon deoxygenation
• slight decrease in in adults
• 37% reduction in neonates
• polymerization of hemoglobin occurs faster than in single Tg(LCR-HBA2,LCR-HBB*)1Cos mice
• increase in mean cell hemoglobin concentration
• slight decrease in mean cell volume

homeostasis/metabolism
• mutants are extremely sensitive to hypoxia, with 9 of 10 mice dying within 90 min of exposure to 8% oxygen

immune system
• large spleen in all adults

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
sickle cell anemia DOID:10923 OMIM:603903
J:94193


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
05/17/2022
MGI 6.19
The Jackson Laboratory