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Phenotypes Associated with This Genotype
Genotype
MGI:5509192
Allelic
Composition		 Arpc3tm1Ssod/Arpc3tm1Ssod
Gt(ROSA)26Sortm2(CAG-tdTomato)Fawa/Gt(ROSA)26Sor+
Tg(Thy1-cre/ERT2,-EYFP)VGfng/0
Genetic
Background		 involves: C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Arpc3tm1Ssod mutation (0 available); any Arpc3 mutation (14 available)
Gt(ROSA)26Sortm2(CAG-tdTomato)Fawa mutation (0 available); any Gt(ROSA)26Sor mutation (1062 available)
Tg(Thy1-cre/ERT2,-EYFP)VGfng mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal dendritic spine morphology ( J:196577 )
• by 4 and 8 weeks after tamoxifen treatment, neurons exhibit a progressive reduction of spine density in the stratum radiatum compared with control neurons
• tamoxifen-treated neurons exhibit a decreased fraction of mushroom type spines and increased filopodia-like spines compared with control neurons

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
01/06/2026
MGI 6.24 		The Jackson Laboratory