Phenotypes for Gt(ROSA)26Sor Tg(Mrgpra3-GFP/cre)#Xzd Trpv1 MGI:5506549 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Gt(ROSA)26Sor^{tm1(Trpv1,ECFP)Mde}/Gt(ROSA)26Sor⁺ Trpv1^tm1Jul/Trpv1^tm1Jul Tg(Mrgpra3-GFP/cre)#Xzd/0
Genetic Background	involves: 129P2/OlaHsd * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{tm1(Trpv1,ECFP)Mde} mutation (1 available); any Gt(ROSA)26Sor mutation (1098 available)
Tg(Mrgpra3-GFP/cre)#Xzd mutation (0 available)
Trpv1^tm1Jul mutation (1 available); any Trpv1 mutation (61 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

hypoalgesia ( J:197482 )

• cheek injection of capsaicin does not evoke pain behavior (forepaw facial wiping), in contrast to robust facial wiping observed in treated wild-type

increased thermal nociceptive threshold ( J:197482 )

• mice have impaired nociceptive responses, showing increased latencies in tail-immersion and hot plate paradigms

integument

increased pruritus ( J:197482 )

• robust itch behavior is observed after cheek injection of capsaicin compared to little hindpaw scratching seen in treated wild-type

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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