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Phenotypes Associated with This Genotype
Genotype
MGI:5505899
Allelic
Composition
Rnf168Gt(156B6)Cmhd/Rnf168Gt(156B6)Cmhd
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rnf168Gt(156B6)Cmhd mutation (0 available); any Rnf168 mutation (43 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
• increased vacuolization at 12 months (J:198260)
• increased vacuolization at 12 months (J:198260)
• at 12 months but not 8 weeks (J:198260)
• at 12 months but not 8 weeks (J:198260)
• at 12 months but not 8 weeks (J:198260)
• at 12 months but not 8 weeks (J:198260)
• increased vacuolization at 12 months (J:198260)
• increased vacuolization at 12 months (J:198260)
• lack or reduced number of spermatids in seminiferous tubules at 12 months (J:198260)
• lack or reduced number of spermatids in seminiferous tubules at 12 months (J:198260)
• at 12 months but not 8 weeks (J:198260)
• at 12 months but not 8 weeks (J:198260)

immune system
N
• T cell and stimulated B cell proliferation is normal (J:198260)
• T cell and stimulated B cell proliferation is normal (J:198260)
• directly impaired class switch recombination (J:198260)
• lower frequency of Smu-Sgamma1 switch recombination (J:198260)
• increased frequency of long nucleotide insertions at the class switch recombination junctions (J:198260)
• directly impaired class switch recombination (J:198260)
• lower frequency of Smu-Sgamma1 switch recombination (J:198260)
• increased frequency of long nucleotide insertions at the class switch recombination junctions (J:198260)
• reduced (J:198260)
• reduced (J:198260)
• in the thymus (J:198260)
• in the thymus (J:198260)
• at 6 to 8 weeks and 9 to 12 months (J:198260)
• at 6 to 8 weeks and 9 to 12 months (J:198260)
• fewer IgG1-expressing B cells in Peyer's patches (J:198260)
• reduced secretion from B cells stimulated with LPS and IL4 (J:198260)
• fewer IgG1-expressing B cells in Peyer's patches (J:198260)
• reduced secretion from B cells stimulated with LPS and IL4 (J:198260)
• reduced secretion from B cells stimulated with LPS and IL4 (J:198260)
• reduced secretion from B cells stimulated with LPS and IL4 (J:198260)
• fewer IgG3-expressing B cells in Peyers patches (J:198260)
• reduced secretion from B cells stimulated with LPS and IL4 (J:198260)
• fewer IgG3-expressing B cells in Peyers patches (J:198260)
• reduced secretion from B cells stimulated with LPS and IL4 (J:198260)

cellular
• irradiated mouse embryonic fibroblasts accumulate at the G2/M phase (J:198260)
• however, activation of the G1/S checkpoint is normal (J:198260)
• irradiated mouse embryonic fibroblasts accumulate at the G2/M phase (J:198260)
• however, activation of the G1/S checkpoint is normal (J:198260)
• in lymphocytes (J:198260)
• in lymphocytes (J:198260)
• in lymphocytes (J:198260)
• in lymphocytes (J:198260)
• spontaneous chromosome aberration in LPS stimulated B cells (J:198260)
• following exposure to ionizing radiation (J:198260)
• spontaneous chromosome aberration in LPS stimulated B cells (J:198260)
• following exposure to ionizing radiation (J:198260)

tumorigenesis
N
• mice do not develop tumors over a 1 year period (J:198260)
• mice do not develop tumors over a 1 year period (J:198260)

endocrine/exocrine glands
• increased vacuolization at 12 months (J:198260)
• increased vacuolization at 12 months (J:198260)
• at 12 months but not 8 weeks (J:198260)
• at 12 months but not 8 weeks (J:198260)
• at 12 months but not 8 weeks (J:198260)
• at 12 months but not 8 weeks (J:198260)

hematopoietic system
• directly impaired class switch recombination (J:198260)
• lower frequency of Smu-Sgamma1 switch recombination (J:198260)
• increased frequency of long nucleotide insertions at the class switch recombination junctions (J:198260)
• directly impaired class switch recombination (J:198260)
• lower frequency of Smu-Sgamma1 switch recombination (J:198260)
• increased frequency of long nucleotide insertions at the class switch recombination junctions (J:198260)
• reduced (J:198260)
• reduced (J:198260)
• in the thymus (J:198260)
• in the thymus (J:198260)
• at 6 to 8 weeks and 9 to 12 months (J:198260)
• at 6 to 8 weeks and 9 to 12 months (J:198260)
• fewer IgG1-expressing B cells in Peyer's patches (J:198260)
• reduced secretion from B cells stimulated with LPS and IL4 (J:198260)
• fewer IgG1-expressing B cells in Peyer's patches (J:198260)
• reduced secretion from B cells stimulated with LPS and IL4 (J:198260)
• reduced secretion from B cells stimulated with LPS and IL4 (J:198260)
• reduced secretion from B cells stimulated with LPS and IL4 (J:198260)
• fewer IgG3-expressing B cells in Peyers patches (J:198260)
• reduced secretion from B cells stimulated with LPS and IL4 (J:198260)
• fewer IgG3-expressing B cells in Peyers patches (J:198260)
• reduced secretion from B cells stimulated with LPS and IL4 (J:198260)

Mouse Models of Human Disease
OMIM ID Ref(s)
Riddle Syndrome 611943 J:198260


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
01/26/2016
MGI 6.02
The Jackson Laboratory