Phenotypes Associated with This Genotype

Genotype
MGI:5501520

• Allelic Composition: Tg(Col1a1-cre)1Kry/0; Vdr^tm2Ska/Vdr^tm2Ska
• Genetic Background: involves: C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

skeleton phenotype ( J:196471 )

N • osteoblasts exhibit normal mineral metabolism

N • cortical thickness in the femur is normal at 16 weeks

abnormal osteoclast differentiation ( J:196471 )

• impaired

decreased osteoclast cell number ( J:196471 )

increased bone mineral density ( J:196471 )

• at 16 weeks

increased trabecular bone volume ( J:196471 )

• at 16 weeks

• however, trabecular bone volume of the distal femoral metaphysis at 4 and 9 weeks is normal

increased bone mass ( J:196471 )

• at 16 weeks

decreased bone resorption ( J:196471 )

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:196471 )

N • mice exhibit normocalcemia and normophosphatemia

cellular

abnormal osteoclast differentiation ( J:196471 )

• impaired

immune system

abnormal osteoclast differentiation ( J:196471 )

• impaired

decreased osteoclast cell number ( J:196471 )

hematopoietic system

abnormal osteoclast differentiation ( J:196471 )

• impaired

decreased osteoclast cell number ( J:196471 )