Phenotypes Associated with This Genotype

Genotype
MGI:5499849

• Allelic Composition: Mecp2^tm1.1Bird/Y
• Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:198551 )

• however, treatment with fluvastatin improves lifespan

behavior/neurological

lethargy ( J:198551 )

decreased startle reflex ( J:198551 )

• even in mice treated with fluvastatin

limb grasping ( J:198551 )

tremors ( J:198551 )

impaired coordination ( J:198551 )

• however, treatment with fluvastatin or lovastatin improves coordination

decreased locomotor activity ( J:198551 )

• however, treatment with fluvastatin or lovastatin improves open-field activity

homeostasis/metabolism

increased circulating cholesterol level ( J:198551 )

• at P56

• however, statin treatment decreases serum cholesterol concentrations

increased circulating LDL cholesterol level ( J:198551 )

• at P56

increased circulating triglyceride level ( J:198551 )

• at P56

increased brain cholesterol level ( J:198551 )

• at P56, but not P70

increased liver triglyceride level ( J:198551 )

• at P56

• however, treatment with fluvastatin or lovastatin improves liver lipid levels

craniofacial

malocclusion ( J:198551 )

growth/size/body

malocclusion ( J:198551 )

decreased body weight ( J:198551 )

liver/biliary system

increased liver triglyceride level ( J:198551 )

• at P56

• however, treatment with fluvastatin or lovastatin improves liver lipid levels

respiratory system

increased pulmonary respiratory rate ( J:198551 )

• even in mice treated with fluvastatin

skeleton

malocclusion ( J:198551 )

nervous system

increased brain cholesterol level ( J:198551 )

• at P56, but not P70