Phenotypes Associated with This Genotype

Genotype
MGI:5496428

• Allelic Composition: Ncstn^tm1.1Akli/Ncstn^tm1.1Akli; Tet2^tm1.1Iaai/Tet2^tm1.1Iaai; Tg(VAV1-cre)1Graf/0
• Genetic Background: involves: 129S/SvEv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:196407 )

• mice die at 26 weeks

immune system

enlarged spleen ( J:196407 )

• with massive infiltration of differentiated and blast-like myeloid cells

myeloid hyperplasia ( J:196407 )

• increased circulating blast-like cells at 7 weeks after birth

• massive infiltration of differentiated and blast-like myeloid cells in the spleen

increased leukocyte cell number ( J:196407 )

• with an increase in absolute myelomonocytic and blast-like cells 7 weeks after birth

neoplasm

abnormal tumor pathology ( J:196407 )

• spleen tumor cells transplanted into lethally irradiated recipients induce increased myeloid cell counts in peripheral blood and lethality compared with cells from control mice

increased leukemia incidence ( J:196407 )

• massive infiltration of differentiated and blast-like myeloid cells in the spleen

hematopoietic system

enlarged spleen ( J:196407 )

• with massive infiltration of differentiated and blast-like myeloid cells

abnormal common myeloid progenitor cell morphology ( J:196407 )

• enlarged granulocyte-macrophage progenitor (GMP) compartment

myeloid hyperplasia ( J:196407 )

• increased circulating blast-like cells at 7 weeks after birth

• massive infiltration of differentiated and blast-like myeloid cells in the spleen

increased leukocyte cell number ( J:196407 )

• with an increase in absolute myelomonocytic and blast-like cells 7 weeks after birth

growth/size/body

enlarged spleen ( J:196407 )

• with massive infiltration of differentiated and blast-like myeloid cells