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Phenotypes Associated with This Genotype
Genotype
MGI:5496424
Allelic
Composition		 Gt(ROSA)26Sortm1Iaai/Gt(ROSA)26Sortm9(cre/ESR1)Arte
Genetic
Background		 involves: C57BL/6 * C57BL/6NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1Iaai mutation (0 available); any Gt(ROSA)26Sor mutation (1084 available)
Gt(ROSA)26Sortm9(cre/ESR1)Arte mutation (3 available); any Gt(ROSA)26Sor mutation (1084 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal bone marrow cell physiology ( J:196407 )
• hematopoietic stem and progenitor cells (HSPCs) infected with MLL-AF9 and transplanted in lethally irradiated recipients treated with tamoxifen produce fewer white blood cells compared with control cells
• bone marrow HSPCs infected with MLL-AF9 or AML1-ETO and treated with tamoxifen exhibit reduced colony number and loss of blast colony morphology unlike control cells

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
01/28/2026
MGI 6.24 		The Jackson Laboratory