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Phenotypes Associated with This Genotype
Genotype
MGI:5495978
Allelic
Composition		 Brca1tm2Cxd/Brca1tm2Cxd
Trp53bp1tm1Jc/Trp53bp1tm1Jc
Cd19tm1(cre)Cgn/Cd19+
Genetic
Background		 involves: 129P2/OlaHsd * 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brca1tm2Cxd mutation (3 available); any Brca1 mutation (113 available)
Cd19tm1(cre)Cgn mutation (12 available); any Cd19 mutation (57 available)
Trp53bp1tm1Jc mutation (1 available); any Trp53bp1 mutation (100 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
cellular phenotype ( J:197442 )
N
• chromosomal damage induced by PARP-inhibition is rescued compared to in cells from Brca1tm2Cxd/Brca1tm2Cxd Cd19tm1(cre)Cgn/Cd19+ mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/06/2026
MGI 6.24 		The Jackson Laboratory