Phenotypes Associated with This Genotype

Genotype
MGI:5495325

• Allelic Composition: Cdc42^tm1.1Rac/Cdc42^tm1.1Rac; Tg(GFAP-cre)25Mes/0
• Genetic Background: involves: 129P2/OlaHsd * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:197886 )

• more than half of mice die before 3 months of age due to severe hydrocephalus

nervous system

hydrocephaly ( J:197886 )

• severe

abnormal brain ventricle morphology ( J:197886 )

• ependymal cells are detached from the lateral and third ventricle

abnormal brain ependyma morphology ( J:197886 )

• ependymal cells are detached from the lateral and third ventricle

absent brain ependyma motile cilia ( J:197886 )

enlarged lateral ventricles ( J:197886 )

enlarged third ventricle ( J:197886 )

thin cerebral cortex ( J:197886 )

craniofacial

domed cranium ( J:197886 )

• in most mice at 4 weeks

skeleton

domed cranium ( J:197886 )

• in most mice at 4 weeks

cellular

absent brain ependyma motile cilia ( J:197886 )