Phenotypes Associated with This Genotype

Genotype
MGI:5495301

• Allelic Composition: Gt(ROSA)26Sor^{tm1(cre/ERT)Nat}/Gt(ROSA)26Sor^{tm4(EWSR1/ATF1)Mrc}
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

decreased litter size ( J:194308 )

growth/size/body

postnatal growth retardation ( J:194308 )

• administration of tamoxifen prior to 3 weeks of age results in stunted growth

mortality/aging

premature death ( J:194308 )

• administration of tamoxifen prior to 3 weeks of age results in death by 12 weeks of age without tumor formation

neoplasm

increased tumor incidence ( J:194308 )

• when tamoxifen is administered after 3 weeks of age more tumors form than without tamoxifen

• tumors most often in extremities, rib cage, and facial tissue

• tumors rare in dermis, liver, and bone

increased sarcoma incidence ( J:217462 )

• mice develop clear cell sarcoma mimicking tumors across a broad anatomic distribution at 3-6 months of age in the absence of tamoxifen, indicating leakiness of the cre transgene

increased tumor latency ( J:194308 )

• all mice have tumors by 12 weeks regardless of treatment