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Phenotypes Associated with This Genotype
Genotype
MGI:5494634
Allelic
Composition		 Cdkn1atm1Led/Cdkn1atm1Led
Hdac2tm1.2Rdp/Hdac2tm1.2Rdp
Genetic
Background		 involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn1atm1Led mutation (1 available); any Cdkn1a mutation (62 available)
Hdac2tm1.2Rdp mutation (1 available); any Hdac2 mutation (39 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal mitosis ( J:197818 )
• senescence-like G1 cell cycle arrest
early cellular replicative senescence ( J:197818 )
• senescence-like G1 cell cycle arrest

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory