Mouse Genome Informatics
cn
    Cdkn2atm4Rdp/Cdkn2atm4Rdp
Krastm4Tyj/Kras+

involves: 129S4/SvJae
Key:
phenotype observed in females
phenotype observed in males
N normal phenotype
tumorigenesis
• mice develop multiple, aggressive adenocarcinomas in the lungs bilaterally following intranasal delivery of an adenovirus expressing Cre recombinase
• tumor growth is reduced more following two 7.3 Gy fractions of radiation therapy than a single 11.6 Gy fraction
• tumors have decreased BrdU uptake 4 hours after radiation treatment compared to unirradiated tumors, indicating the presence of an intact G1 cell-cycle checkpoint

Mouse Models of Human Disease
OMIM IDRef(s)
Lung Cancer 211980 J:195492